The Biomedical Information Science and Technology Initiative is a consortium of representatives from each of the NIH institutes and centers. BISTI was established in May 2000 to serve as the focus of biomedical computing, informatics and data science related issues at the NIH and falls under the NIH Scientific Data Council.

The mission of BISTI is to make optimal use of computer science and related technology to address problems in biology and medicine by fostering new basic understandings, collaborations, and transdisciplinary initiatives between the computational and biomedical sciences.

In support of this mission, the BISTI coordinates research grants, training opportunities, and scientific symposia associated with biomedical computing. Regular monthly meetings are conducted to discuss program status, future needs and directions, and topics of interest to the biomedical computational and informatics community.​​